The Lords of Salem, as you have probably guessed, is about witches and is taken from a song with the same name off Zombie's 2006 album "Educated Horses." From the little that we know about this upcoming film, a coven of witches who were executed during the witch trials of Salem, Massachusetts in 1692 return to the present day to exact their revenge on the town. According to Rob Zombie via /Film:
There were twenty people that everyone knows about – obviously all innocent – executed as witches in Salem. The basic premise of the film is that there were a further four who actually were witches, who were killed secretly, and vowed one day to return to wreak havoc on Salem’s descendants. That’s when the movie jumps ahead to the present day and things start to go wrong…Zombie has also mentioned that this will be his "bleakest" film yet, which if you've seen his other movies should have you worried... in a good way. Shooting will begin mid-April.
Here is the video for the 2006 song "The Lords of Salem" if you want an idea of who will be wearing that mask in the above photo.